Asla Pitkänen Selected Research

Post-Traumatic Epilepsy (Epilepsy, Post Traumatic)

1/2021	Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis.
12/2020	Early Increase in Cortical T2 Relaxation Is a Prognostic Biomarker for the Evolution of Severe Cortical Damage, but Not for Epileptogenesis, after Experimental Traumatic Brain Injury.
10/2019	Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium.
10/2019	Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis.
10/2019	Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis.
1/2019	Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis.
1/2019	Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis.
10/2017	Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy.
1/2017	Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid Eye Movement Sleep.

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Asla Pitkänen Research Topics

Disease

66	Epilepsy (Aura) 01/2022 - 01/2002
31	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 04/2004
29	Seizures (Absence Seizure) 12/2021 - 01/2002
23	Status Epilepticus (Complex Partial Status Epilepticus) 01/2019 - 02/2002
11	Temporal Lobe Epilepsy 01/2017 - 01/2002
9	Post-Traumatic Epilepsy (Epilepsy, Post Traumatic) 01/2021 - 01/2017
9	Brain Injuries (Brain Injury) 01/2020 - 01/2007
5	Neoplasms (Cancer) 01/2021 - 06/2003
4	Neuroinflammatory Diseases 01/2022 - 10/2019
4	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 03/2011
4	Brain Diseases (Brain Disorder) 03/2019 - 02/2007
4	Stroke (Strokes) 01/2016 - 04/2003
3	Atrophy 01/2022 - 06/2010
3	Inflammation (Inflammations) 01/2020 - 11/2017
3	Gliosis 01/2019 - 07/2002
3	Cognitive Dysfunction 12/2016 - 06/2004
2	Hydrocephalus (Hydrocephaly) 01/2022 - 02/2007
2	Brain Concussion (Cerebral Concussion) 02/2021 - 10/2019
2	Amyloid Plaque 01/2016 - 05/2015
2	Nervous System Diseases (Neurological Disorders) 06/2008 - 01/2002
1	Sleep Deprivation 05/2022
1	Infections 12/2021
1	Body Weight (Weight, Body) 01/2020
1	Necrosis 10/2019
1	Weight Loss (Weight Reduction) 10/2019
1	Reinjuries 10/2019
1	Apnea 01/2019
1	Partial Epilepsies (Epilepsy, Partial) 01/2018

Drug/Important Bio-Agent (IBA)

38	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2007
12	Anticonvulsants (Antiepileptic Drugs)IBA 12/2017 - 06/2002
11	Kainic Acid (Kainate)IBA 01/2017 - 02/2002
10	Pharmaceutical PreparationsIBA 01/2021 - 05/2003
7	salicylhydroxamic acid (SHAM)IBA 05/2022 - 01/2007
6	MicroRNAs (MicroRNA)IBA 02/2021 - 11/2017
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2007
5	Pentylenetetrazole (Metrazol)IBA 12/2021 - 06/2010
5	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2019 - 03/2010
4	Pilocarpine (Ocusert)FDA LinkGeneric 01/2017 - 06/2004
4	Cystatin CIBA 03/2006 - 01/2002
3	IronIBA 01/2022 - 01/2019
3	Amyloid (Amyloid Fibrils)IBA 12/2016 - 05/2015
3	LigandsIBA 01/2016 - 01/2014
3	Valproic Acid (Depakote)FDA LinkGeneric 05/2015 - 02/2007
3	Neuropeptide YIBA 04/2009 - 02/2007
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2021 - 10/2019
2	NitritesIBA 09/2021 - 10/2019
2	AlbuminsIBA 11/2020 - 01/2018
2	Trimipramine (Surmontil)FDA LinkGeneric 10/2019 - 01/2018
2	Sirolimus (Rapamycin)FDA Link 10/2019 - 01/2016
2	Urokinase Plasminogen Activator ReceptorsIBA 01/2019 - 06/2013
2	Messenger RNA (mRNA)IBA 11/2017 - 09/2003
2	atipamezoleIBA 10/2017 - 09/2004
2	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 10/2015
2	GABA-A Receptors (GABA(A) Receptor)IBA 01/2016 - 09/2003
2	Ion Channels (Ion Channel)IBA 01/2016 - 01/2014
2	gamma-Aminobutyric Acid (GABA)IBA 01/2014 - 09/2003
2	MedetomidineIBA 07/2012 - 10/2010
2	ManganeseIBA 10/2011 - 05/2008
2	Sodium Channels (Sodium Channel)IBA 03/2011 - 04/2007
2	Carbamazepine (Tegretol)FDA LinkGeneric 03/2011 - 02/2007
2	ThioninsIBA 06/2010 - 05/2008
2	GalaninIBA 04/2009 - 02/2007
2	NeuropeptidesIBA 04/2009 - 02/2007
2	fluoro jadeIBA 05/2008 - 01/2002
2	Cysteine Proteinase InhibitorsIBA 03/2006 - 11/2005
1	Small Untranslated RNAIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	LipopolysaccharidesIBA 12/2021
1	ParvalbuminsIBA 11/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2021
1	AntioxidantsIBA 09/2021
1	ClusterinIBA 12/2019
1	IonomycinIBA 10/2019
1	desmethylclomipramineIBA 10/2019
1	CytokinesIBA 10/2019
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2019
1	CalciumIBA 10/2019
1	Choline (Choline Chloride)IBA 01/2019
1	Inositol (Myoinositol)IBA 01/2019
1	ferric ferrocyanide (Prussian blue)FDA Link 01/2019
1	Glutathione (Reduced Glutathione)IBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Antipsychotic Agents (Antipsychotics)IBA 01/2018
1	Tamoxifen FDA LinkGeneric 01/2018
1	HMGB1 Protein (HMG1)IBA 01/2018
1	Fluspirilene (Imap)IBA 01/2018
1	Isoflurane FDA LinkGeneric 01/2018
1	Chlorpromazine (Thorazine)FDA Link 01/2018
1	Losartan (Cozaar)FDA LinkGeneric 01/2018
1	Antidepressive Agents (Antidepressants)IBA 01/2018
1	AntibodiesIBA 01/2018
1	Adenosine (Adenocard)FDA LinkGeneric 01/2018

Therapy/Procedure

26	Therapeutics 01/2022 - 04/2003
2	Anesthesia 01/2019 - 10/2010
2	Electrodes (Electrode) 01/2018 - 10/2010
2	Aftercare (After-Treatment) 10/2017 - 05/2015
1	Secondary Prevention 01/2021
1	Operative Surgical Procedures 10/2019
1	Drug Therapy (Chemotherapy) 01/2018
1	Topical Administration 01/2018